Purchase Bactrim tablets online
How and where to order Bactrim, Bactrim DS, Septra, Co-Trimoxazole (Sulfamethoxazole/Trimethoprim) 400/80 mg, 800/160 mg tablets online:
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Type: Bactrim, Bactrim DS, Septra, Co-Trimoxazole generic
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Indications and usage:
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Sulfamethoxazole with Trimethoprim and other antibacterial drugs, Bactrim, Bactrim DS (double strength), and Septra should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Bactrim and Septra are contraindicated in patients with the following:
The amount of a single dose of Septra or Bactrim that is either associated with symptoms of overdosage or is likely to be life-threatening has not been reported. Signs and symptoms of overdosage reported with sulfonamides include anorexia, colic, nausea, vomiting, dizziness, headache, drowsiness, and unconsciousness. Pyrexia, hematuria, and crystalluria may be noted. Blood dyscrasias and jaundice are potential late manifestations of overdosage. Signs of acute overdosage with trimethoprim include nausea, vomiting, dizziness, headache, mental depression, confusion, and bone marrow depression.
General principles of treatment include the institution of gastric lavage or emesis; forcing oral fluids; and the administration of intravenous fluids if urine output is low and renal function is normal. Acidification of the urine will increase renal elimination of trimethoprim. The patient should be monitored with blood counts and appropriate blood chemistries, including electrolytes. If a significant blood dyscrasia or jaundice occurs, specific therapy should be instituted for these complications. Peritoneal dialysis is not effective and hemodialysis is only moderately effective in eliminating trimethoprim and sulfamethoxazole.
Use of Sulfamethoxazole and Trimethoprim at high doses and/or for extended periods of time may cause bone marrow depression manifested as thrombocytopenia, leukopenia, and/or megaloblastic anemia. If signs of bone marrow depression occur, the patient should be given leucovorin; 5 to 15 mg leucovorin daily has been recommended by some investigators.
Potential for Septra and Bactrim to affect other drugs: diuretics, warfarin, phenytoin, methotrexate, cyclosporine, digoxin, indomethacin, pyrimethamine, tricyclic antidepressants (TCAs), oral hypoglycemics, amantadine, angiotensin converting enzyme inhibitors, zidovudine, dofetilide, procainamide.
Trimethoprim is an inhibitor of CYP2C8 as well as OCT2 transporter. Sulfamethoxazole is an inhibitor of CYP2C9. Caution is recommended when this medication is co-administered with drugs that are substrates of CYP2C8 and 2C9 or OCT2.
Information for patients:
Patients should be counseled that antibacterial drugs including Bactrim and Septra should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When this medicine is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may decrease the effectiveness of the immediate treatment and increase the likelihood that bacteria will develop resistance and will not be treatable with sulfamethoxazole/trimethoprim or other antibacterial drugs in the future.
Patients should be instructed to maintain an adequate fluid intake in order to prevent crystalluria and stone formation.
Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible.
Adverse reactions, side effects:
The most common adverse effects of Bactrim and Septra are gastrointestinal disturbances (nausea, vomiting, anorexia) and allergic skin reactions (such as rash and urticaria). Fatalities associated with the administration of sulfonamides have occurred due to severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS), fulminant hepatic necrosis, agranulocytosis, aplastic anemia, other blood dyscrasias, acute and delayed lung injury, anaphylaxis, and circulatory shock.
Use in specific populations:
While there are no large, well-controlled studies on the use of trimethoprim and sulfamethoxazole in pregnant women, Brumfitt and Pursell in a retrospective study, reported the outcome of 186 pregnancies during which the mother received either placebo or trimethoprim and sulfamethoxazole. The incidence of congenital abnormalities was 4.5% (3 of 66) in those who received placebo and 3.3% (4 of 120) in those receiving trimethoprim and sulfamethoxazole. There were no abnormalities in the 10 children whose mothers received the drug during the first trimester. In a separate survey, Brumfitt and Pursell also found no congenital abnormalities in 35 children whose mothers had received oral trimethoprim and sulfamethoxazole at the time of conception or shortly thereafter.
Because trimethoprim and sulfamethoxazole may interfere with folic acid metabolism, Septra or Bactrim should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Levels of trimethoprim/sulfamethoxazole in breast milk are approximately 2-5% of the recommended daily dose for infants over 2 months of age. Caution should be exercised when this drug is administered to a nursing woman, especially when breastfeeding jaundiced, ill, stressed, or premature infants because of the potential risk of bilirubin displacement and kernicterus.
This medication is contraindicated for pediatric patients younger than 2 months of age.
Clinical studies of Septra and Bactrim did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.
Where to buy sulfamethoxazole/trimethoprim online:
To purchase Co-Trimoxazole (Bactrim, Bactrim DS, Septra) 400/80 mg, 900/160 mg tablets from reliable online pharmacies and drugstores at low prices please use resources described above on this webpage.
Here is a list of popular medications containing sulfamethoxazole and trimethoprim as main active pharmaceutical ingredients; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:
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